Not sure what type of rig you have, but for the most part I agree with Bill. 101 north to 68 west through Monterrey is just as fast and safer.
I have pulled CA 1 both ways with a 30' SOB fiver and there are a couple of turns that are almost impossible to make. (At Lime Kiln is one bad one). While it has been improved and widened a great deal since the 60's, it's still definitely not for novices or the faint of heart while towing.
Once you drop your trailer, I do recommend making the drive in your tow vehicle however. It's one of America's most scenic drives. Trace