Well, not knowing were in W. Virginia your starting from that limits us if you want to go 250mi and stay two nights in Northeastern Penn. If you started in Elkins WV and went to Allentown PA which is not in Northeastern PA you are looking at about 332 miles..
How about giving us where you are starting from, where you want to end up and how far you want to travel each day or how many days you have to travel to your destination.
We only travel 150 - 250 miles and normally on Monday, Wednesday and Friday.
Let us know and I will tell you where I would go.. BTW We really dislike interstates unless necessary.
BC