I would think that as long as you stay with in your rated limits you would be fine.
Therein lies the problem with half ton trucks, and even 3/4 ton trucks and 5th wheels. I have seen half ton trucks towing 5th wheels and stay away. It is almost impossible to tow a modern 5th wheel RV with any half ton and stay under the trucks' rear axle rating and GVWR. There are exceptions, but generally do not attempt.
Example: half ton truck with 1500 pounds of payload. Some have more, some have less.
Half ton towable 5th wheel RV, 7500 pounds dry.
You needx at least a 150 pound hitch in the bed, so payload is down to 1350 pounds. Auto sliders for short bed trucks are up to 250 pounds.
You, wife, kids, 400 pounds in the truck. Down to 950 pounds of payload available for the trailer pin weight.
5th wheels tow best with 15%-25% pin weight. But the exact placement of the axles will determine that with most in the 20-25% range. So that 7500 pound dry 5er will swell to 8500 pounds with options and camping supplies. Even if you found one with a minimum 15% pin weight and you loaded nothing in the basement storage (isn't that one of the best features of a 5er?) and nothing in the bedroom over the pin, that is 1275 pounds, already 325 pounds over the truck's GVWR. But most people pack front heavy on any RV because that is where the larger storage areas are. So 8500 pounds loaded, 20
% pin weight, that's 1700 pounds, plus the light hitch and people and now you need more like 2250 pounds of payload to pull one of the ultralite half ton towable 5ers.
Now you can imagine how a 3/4 ton truck gets quickly overloaded with it's mere 2500-3000 pounds of payload. A modest 10k pound 5er, 2000 pounds on the pin, a family of 4, the hitch, and you're at the GVWR, despite having 700+lb-ft of torque to move it.
Now there are some half tons that have had up to 3k pounds of payload over the last 10 years. No 2010 models, though. If you want a crew cab half ton, think 1900 pounds tops, and that is the 2010 F-150 with Max Tow Package. As mentioned, not all are equal. There exist some half ton pickups with door stickers showing payload less than 800 pounds, which is lower than my little Jeep and my minivan.
I highly recommend a 1-ton with at least 4500 pounds of payload for people considering 5ers. 3/4 ton is good for the largest TTs. The little half tons (I have one and plan to get another) should carefully choose their lightweight TT.